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Letrozole is used in bodybuilding primarily for its ability to reduce estrogen levels in the body. It is an aromatase inhibitor, originally developed to treat hormone-responsive breast cancer in postmenopausal women. In bodybuilding, Letrozole is often used during or after anabolic steroid cycles. As post-cycle therapy it's used to help restore hormonal balance by reducing estrogen and indirectly encouraging the body's natural testosterone production.